Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of (R)-Tolterodine.
نویسندگان
چکیده
منابع مشابه
Rhodium/phosphoramidite-catalyzed asymmetric arylation of aldehydes with arylboronic acids.
Phosphoramidites are effective chiral ligands in the rhodium catalyzed addition of arylboronic acids to aldehydes providing up to 75% enantioselectivity and up to 96% isolated yield.
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An efficient rhodium/olefin-sulfoxide catalyzed asymmetric conjugate addition of organoboronic acids to a variety of nitroalkenes has been developed, where 2-methoxy-1-naphthyl sulfinyl functionalized olefin ligands have shown to be highly effective and are applicable to a broad scope of aryl, alkyl, and heteroaryl nitroalkenes.
متن کاملEnantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones.
The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.
متن کاملRhodium-Catalyzed Addition of Arylboronic Acids to N-Sulfonyl Aldimines
The addition of arylboronic acids, ArB(OH)2, to N-phenylsulfonyl aldimines, RCH=NSO2Ph (R=alkyl, aryl, 1-alkenyl), giving R(Ar)CHNHSO2Ph was carried out at 95 °C in the presence of a rhodium catalyst. [Rh(cod)(MeCN)2]BF4 (3 mol%) was found to be the best catalyst for aryl aldimines and Rh(acac)(coe)2/i-Pr3P for alkyl and 1-alkenyl aldimines. The analogous reactions of arylboronic esters, such a...
متن کاملRhodium-catalyzed asymmetric addition of arylboroxines to β-alkoxyacrylate esters.
Asymmetric addition of arylboroxines to β-alkoxyacrylate esters proceeded in the presence of a rhodium complex coordinated with a chiral diene ligand to give high yields of β-alkoxy-β-arylcarboxylic acid esters with very high enantioselectivity.
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ژورنال
عنوان ژورنال: ChemInform
سال: 2005
ISSN: 0931-7597,1522-2667
DOI: 10.1002/chin.200542153